Erro de citação: Etiqueta <ref>
inválida; refs sem parâmetro de nome devem ter conteúdo associado
DRD2 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/d/da/7jvr_Dopamine_receptor_D2.png/250px-7jvr_Dopamine_receptor_D2.png) |
Estruturas disponíveis |
---|
PDB | Pesquisa Human UniProt: PDBe RCSB |
---|
Lista de códigos id do PDB |
---|
6CM4 |
|
|
Identificadores |
---|
Nomes alternativos | DRD2 |
---|
IDs externos | OMIM: 126450 HomoloGene: 22561 GeneCards: DRD2 |
---|
|
Doenças Geneticamente Relacionadas |
---|
depressão nervosa[1] |
|
Targeted by Drug |
---|
remoxipride[2] |
benzquinamide, LP-12, LP-211, LP-44, Ropinirol, Rotigotina, Vilazodona, 7-hydroxy-2-(di-N-propylamino)tetralin, bromocriptina, dopamina, pergolide, pramipexole, quinelorane, quinpirole, sumanirole, apomorfina, aripiprazol, Brexpiprazol, cabergolina, lisurida, piribedil, roxindole, Tergurida, amissulprida, blonanserin, (+)-butaclamol, clorpromazina, clozapina, domperidona, eticlopride, Flupentixol, flufenazina, haloperidol, L-741,626, loxapina, mesoridazine, nafadotride, olanzapina, perospirone, perphenazine, pimozida, pipotiazine, prochlorperazine, promazina, quetiapina, raclopride, risperidona, sertindole, (RS)-sulpiride, levosulpiride, trifluoperazina, ziprasidona, zotepina[3] |
Ontologia genética |
---|
Função molecular | • protein homodimerization activity • potassium channel regulator activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • identical protein binding • dopamine neurotransmitter receptor activity • G protein-coupled receptor activity • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • signal transducer activity • adrenergic receptor activity • dopamine binding • signaling receptor binding • ionotropic glutamate receptor binding • protein heterodimerization activity
|
---|
Componente celular | • GO:0016023 cytoplasmic vesicle • sperm flagellum • endocytic vesicle • Acrossoma • Espinha dendrítica • synaptic vesicle membrane • soma • membrana plasmática • dendrito • ciliary membrane • axon terminus • integral component of membrane • GO:0097483, GO:0097481 postsynaptic density • membrane • lateral plasma membrane • axónio • intracellular anatomical structure • non-motile cilium • integral component of plasma membrane • dopaminergic synapse • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane • integral component of presynaptic membrane
|
---|
Processo biológico | • negative regulation of cell population proliferation • temperature homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenohypophysis development • circadian regulation of gene expression • response to toxic substance • regulation of dopamine secretion • response to cocaine • response to amphetamine • sensory perception of smell • locomotory behavior • positive regulation of urine volume • response to ethanol • axonogenesis • response to inactivity • phospholipase C-activating dopamine receptor signaling pathway • modulation of chemical synaptic transmission • grooming behavior • negative regulation of protein kinase B signaling • associative learning • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • regulation of dopamine uptake involved in synaptic transmission • regulation of synaptic transmission, GABAergic • positive regulation of dopamine uptake involved in synaptic transmission • GO:0072468 transdução de sinal • Via de sinalização Wnt • adult walking behavior • branching morphogenesis of a nerve • negative regulation of cytosolic calcium ion concentration • negative regulation of innate immune response • regulation of phosphoprotein phosphatase activity • acid secretion • feeding behavior • positive regulation of G protein-coupled receptor signaling pathway • response to axon injury • striatum development • synaptic transmission, dopaminergic • nervous system process involved in regulation of systemic arterial blood pressure • movimento peristáltico • regulation of long-term neuronal synaptic plasticity • activation of protein kinase activity • positive regulation of growth hormone secretion • regulation of sodium ion transport • forebrain development • response to light stimulus • orbitofrontal cortex development • prepulse inhibition • response to morphine • response to iron ion • positive regulation of ERK1 and ERK2 cascade • memória de longo prazo • positive regulation of renal sodium excretion • negative regulation of insulin secretion • neuron-neuron synaptic transmission • GO:0007243 intracellular signal transduction • auditory behavior • behavioral response to ethanol • regulation of heart rate • adenylate cyclase-activating adrenergic receptor signaling pathway • positive regulation of cytokinesis • regulation of potassium ion transport • pigmentation • cellular calcium ion homeostasis • dopamine metabolic process • response to nicotine • regulation of MAPK cascade • response to histamine • negative regulation of synaptic transmission, glutamatergic • response to hypoxia • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of protein secretion • Sinaptogênese • regulation of locomotion involved in locomotory behavior • dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • startle response • positive regulation of receptor internalization • GO:0034613 protein localization • arachidonic acid secretion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • G protein-coupled receptor internalization • positive regulation of multicellular organism growth • positive regulation of long-term synaptic potentiation • negative regulation of dopamine secretion • adult behavior • cerebral cortex GABAergic interneuron migration • regulation of synapse structural plasticity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • visual learning • negative regulation of cell migration • behavioral response to cocaine • positive regulation of neuroblast proliferation • negative regulation of blood pressure • release of sequestered calcium ion into cytosol • negative regulation of voltage-gated calcium channel activity • G protein-coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • potencial pós-sináptico excitatório • GO:0033128 negative regulation of protein phosphorylation • autofagia • positive regulation of neurogenesis • negative regulation of cell death • drinking behavior • adrenergic receptor signaling pathway • regulation of neurotransmitter uptake • postsynaptic modulation of chemical synaptic transmission • regulation of synaptic vesicle exocytosis
|
---|
Sources:Amigo / QuickGO |
|
|
|
Wikidata |
|
O receptor D2 de dopamina, também conhecido por D2R, é uma proteína que, em seres humanos, é codificada pelo gene DRD2.
Não só é o principal receptor da maioria dos medicamentos antipsicóticos, como foi através destes medicamentos que foi identificado em 1975. Na busca pelo mecanismo fisiopatológico da psicose, a equipe procurou identificar os locais que se ligavam ao medicamento antipsicótico haloperidol.[5]
Este gene codifica o subtipo D2 dos receptores de dopamina. Este receptor acoplado à proteína G inibe a actividade da adenilato ciclase, sendo portanto associado à variante Gi. Uma mutação missence neste gene causa distonia mioclónica; outras mutações têm sido associadas com a esquizofrenia.[6]
O splicing alternativo deste gene resulta em duas variantes de trancriptos que codificam diferentes isoformas[7], D2S (D2-short) e D2L (D2-long).[5][8]
A variante longa (D2L) funciona como um tradicional receptor pós-sináptico. Já a versão curta (D2S) trata-se de um receptor pré-sináptico, que funciona como um autoreceptor, ou seja, pode aumentar ou reduzir a quantidade de dopamina libertada para o espaço extracelular, dependendo da quantidade presente.[8]